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Fig. 4 | Cancer Cell International

Fig. 4

From: Interfering cellular lactate homeostasis overcomes Taxol resistance of breast cancer cells through the microRNA-124-mediated lactate transporter (MCT1) inhibition

Fig. 4

MCT1 is a direct target of miR-124 in breast cancers. a Prediction programs from Targetscan and microRNA.org illustrated 3′UTR region of SLC16A1 mRNA contains complimentary binding sites for the seeding sequence of miR-124. b Western blot analysis of the downregulated expression levels of MCT1 in miR-124 overexpressed MCF7 (left) and SKBR3 (right) cells. β-actin is a loading control. c Luciferase assays showed miR-124 targeted predicted 3′UTR region of MCT1 but not the mutant 3UTR. d Analysis of the negative correlation between MCT1 mRNAs and miR-124 expressions in human breast cancer specimens. **p < 0.01

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