Skip to main content

Advertisement

Fig. 5 | Cancer Cell International

Fig. 5

From: Interfering cellular lactate homeostasis overcomes Taxol resistance of breast cancer cells through the microRNA-124-mediated lactate transporter (MCT1) inhibition

Fig. 5

Combination of Taxol and MCT1 inhibition demonstrates synergistic inhibition on breast cancer cells. a MCF7 cells and (b) BT474 cells were treated with control, Taxol alone, MCT1 inhibitor alone or the combination of Taxol and MCT1 inhibitor at the indicated concentrations for 48 h, the cell viabilities were measured. c MCF7 and (d) BT474 cells were transfected with control miRNA or miR-124 for 48 h, the expressions of miR-124 were measured by qRT-PCR. e MCF7 and (f) BT474 cells were treated with control, Taxol alone, miR-124 overexpression or the combination of Taxol and miR-124 at the indicated concentrations for 48 h, the cell viabilities were measured. *p < 0.05; **p < 0.01; ***p < 0.001

Back to article page