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Table 1 The main features of the included studies on individual miR-29 in the diagnosis of CRC

From: Integrated analyses of microRNA-29 family and the related combination biomarkers demonstrate their widespread influence on risk, recurrence, metastasis and survival outcome in colorectal cancer

First author Year Country Ethnicity Case Control Sample source Methods miRNA AUC Sensitivity Specificity QUADAS
M F N Age M F N Age  
Huang [27] 2010 China Asian 51 49 100 61 31 28 59 58 Plasma RT-PCR miR-29a 0.844 0.69 0.89 3
Giraldez [28] 2013 Spain Caucasian NA NA 21 72.5 11 9 20 60.6 Plasma RT-PCR miR-29a NA 0.62 0.85 4
Luo [29] 2013 Germany Caucasian 45 35 80 68 60 84 144 62.5 Plasma RT-PCR miR-29a 0.571 0.30 0.90 4
Ramzy [34] 2015 Egypt African NA NA 25 46 NA NA 10 NA Serum RT-PCR miR-29a 0.614 0.87 0.33 3
Basati [30] 2015 Iran Asian 30 25 55 58.52 31 24 55 57.9 Serum RT-PCR miR-29b 0.87 0.77 0.75 4
Li [31] 2015 China Asian 135 65 200 66.3 283 117 400 65.5 Tissue RT-PCR miR-29b 0.883 0.82 0.85 4
Li [31] 2015 China Asian 135 65 200 66.3 283 117 400 65.5 Plasma RT-PCR miR-29b 0.743 0.61 0.72 4
Yamada [35] 2015 Japan Asian 93 43 136 68 23 29 52 58 Serum RT-PCR miR-29a 0.741 0.60 0.84 3
Zhu [32] 2016 China Asian 42 38 80 60.7 27 24 51 49.3 Feces RT-PCR miR-29a 0.777 0.85 0.61 4
Liu [33] 2018 China Asian 51 34 85 59.5 48 30 78 34.8 Serum RT-PCR miR-29a 0.878 0.69 0.95 5
  1. M male, F female, N number, NA not available, AUC area under the curve, QUADAS quality assessment of diagnostic accuracy studies