Integrated analyses of microRNA-29 family and the related combination biomarkers demonstrate their widespread influence on risk, recurrence, metastasis and survival outcome in colorectal cancer

Table 2 The main features of the included studies on miR-29-related combination markers in the diagnosis of CRC

First author	Year	Country	Ethnicity	Case				Control				miRNA combinations	Sample source	Methods	AUC	Sensitivity	Specificity	QUADAS
First author	Year	Country	Ethnicity	M	F	N	Age	M	F	N	Age	miRNA combinations	Sample source	Methods	AUC	Sensitivity	Specificity	QUADAS
Huang [27]	2010	China	Asian	51	49	100	61	31	28	59	58	miR-29a, miR-92a	Plasma	RT-PCR	0.883	0.83	0.85	3
Wang [36]	2012	China	Asian	NA	NA	90	NA	NA	NA	58	NA	miR-29a, miR-92a, miR-760	Plasma	RT-PCR	0.943	0.83	0.93	5
Luo [29]	2013	Germany	Caucasian	45	35	80	68	60	84	144	62.5	miR-29a, miR-92a, miR-18a, miR-20a, miR-21, miR-106b, miR-133a, miR-143, miR-145, miR-342-3p, miR-532-3p, miR-181b	Plasma	RT-PCR	0.745	0.72	0.75	4
Yamada [35]	2015	Japan	Asian	93	43	136	68	23	29	52	58	miR-29a, miR-21, miR-125b	Serum	RT-PCR	0.826	0.74	0.85	3
Liu [33]	2018	China	Asian	51	34	85	59.5	48	30	78	34.8	miR-29a, miR-92a	Serum	RT-PCR	0.876	0.73	0.94	5
Liu [33]	2018	China	Asian	51	34	85	59.5	48	30	78	34.8	miR-29a, miR-92a, miR-21, miR-125b	Serum	RT-PCR	0.952	0.85	0.99	5

M male, F female, N number, NA not available, AUC area under the curve, QUADAS quality assessment of diagnostic accuracy studies

ISSN: 1475-2867