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Table 2 The main features of the included studies on miR-29-related combination markers in the diagnosis of CRC

From: Integrated analyses of microRNA-29 family and the related combination biomarkers demonstrate their widespread influence on risk, recurrence, metastasis and survival outcome in colorectal cancer

First author Year Country Ethnicity Case Control miRNA combinations Sample source Methods AUC Sensitivity Specificity QUADAS
M F N Age M F N Age
Huang [27] 2010 China Asian 51 49 100 61 31 28 59 58 miR-29a, miR-92a Plasma RT-PCR 0.883 0.83 0.85 3
Wang [36] 2012 China Asian NA NA 90 NA NA NA 58 NA miR-29a, miR-92a, miR-760 Plasma RT-PCR 0.943 0.83 0.93 5
Luo [29] 2013 Germany Caucasian 45 35 80 68 60 84 144 62.5 miR-29a, miR-92a, miR-18a, miR-20a, miR-21, miR-106b, miR-133a, miR-143, miR-145, miR-342-3p, miR-532-3p, miR-181b Plasma RT-PCR 0.745 0.72 0.75 4
Yamada [35] 2015 Japan Asian 93 43 136 68 23 29 52 58 miR-29a, miR-21, miR-125b Serum RT-PCR 0.826 0.74 0.85 3
Liu [33] 2018 China Asian 51 34 85 59.5 48 30 78 34.8 miR-29a, miR-92a Serum RT-PCR 0.876 0.73 0.94 5
Liu [33] 2018 China Asian 51 34 85 59.5 48 30 78 34.8 miR-29a, miR-92a, miR-21, miR-125b Serum RT-PCR 0.952 0.85 0.99 5
  1. M male, F female, N number, NA not available, AUC area under the curve, QUADAS quality assessment of diagnostic accuracy studies