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Table 3 The main features of the included studies on miR-29 in the prognosis of CRC

From: Integrated analyses of microRNA-29 family and the related combination biomarkers demonstrate their widespread influence on risk, recurrence, metastasis and survival outcome in colorectal cancer

First author Year Country Ethnicity M/F N Age TNM stage Sample source miRNA Methods Endpoints Follow-up time (months) Hazard ratio Scores
Brenner [42] 2011 Israel Asian 34/25 59 78 II Tissue miR-29a RT-PCR DFS NA 0.194 (0.063–0.597) 7
Tang [37] 2014 China Asian 46/39 85 60 I-IV Tissue miR-29a RT-PCR OS 40 1.556 (1.066–2.282) 9
Inoue [38] 2014 Japan Asian 153/92 245 NA I-IV Tissue miR-29b RT-PCR OS 54 0.459 (0.240–0.850) 8
Inoue [38] 2014 Japan Asian 153/92 245 NA I-IV Tissue miR-29b RT-PCR DFS 54 0.452 (0.222–0.915) 7
Basati [30] 2015 Iran Asian 30/25 55 58.5 I-IV Serum miR-29b RT-PCR OS 40 0.142 (0.029–0.342) 7
Yuan [40] 2017 China Asian 81/63 144 56.1 I-IV Plasma miR-29a RT-PCR RFS NA 2.610 (1.340–5.070) 7
Ulivi [39] 2018 Italy Caucasian 35/17 52 65 I-IV Plasma miR-29b RT-PCR OS NA 0.872 (0.753–0.991) 8
Ulivi [39] 2018 Italy Caucasian 35/17 52 65 I-IV Plasma miR-29b RT-PCR PFS NA 0.854 (0.728–0.997) 8
  1. M male, F female, N number, NA not available, DFS disease-free survival, OS overall survival, RFS relapse-free survival, PFS progression-free survival