| Analysis | Number of studies | Se (95%CI) | Sp (95%CI) | AUC (95%CI) |
---|---|---|---|---|---|
Individual | Ethnicity | ||||
 |  Asian | 7 | 0.72 (0.65–0.79) | 0.82 (0.73–0.89) | 0.83 (0.79–0.86) |
 | Sample type | ||||
 |  Plasma | 4 | 0.55 (0.38–0.70) | 0.83 (0.72–0.91) | 0.79 (0.75–0.83) |
 |  Serum | 4 | 0.73 (0.61–0.82) | 0.78 (0.51–0.92) | 0.79 (0.76–0.83) |
 |  Circulating | 8 | 0.65 (0.52–0.76) | 0.82 (0.70–0.90) | 0.80 (0.76–0.83) |
 |  Feces | 1 | 0.85 (0.73–0.93) | 0.61 (0.49–0.71) | 0.78 (0.69–0.86) |
 |  Tissue | 1 | 0.82 (0.75–0.87) | 0.85 (0.81–0.88) | 0.88 |
 | Sample size | ||||
 |  > Median | 5 | 0.61 (0.45–0.76) | 0.86 (0.77–0.92) | 0.84 (0.81–0.87) |
 |  < Median | 5 | 0.78 (0.68–0.85) | 0.73 (0.54–0.86) | 0.82 (0.79–0.85) |
 | miRNA profiling | ||||
 |  miR-29a | 7 | 0.68 (0.52–0.81) | 0.83 (0.67–0.92) | 0.82 (0.79–0.85) |
 |  miR-29b | 3 | 0.72 (0.68–0.77) | 0.77 (0.76–0.81) | 0.86 (0.78–0.94) |
 | Overall | 10 | 0.70 (0.58–0.79) | 0.81 (0.71–0.88) | 0.82 (0.79–0.85) |
 | Outliers excluded | 8 | 0.72 (0.65–0.78) | 0.82 (0.74–0.88) | 0.82 (0.79–0.85) |
Combination | Overall | 6 | 0.78 (0.73–0.82) | 0.91 (0.83–0.95) | 0.86 (0.83–0.89) |