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Table 4 Pooled results of diagnostic accuracy of miR-29 and combination biomarkers in CRC

From: Integrated analyses of microRNA-29 family and the related combination biomarkers demonstrate their widespread influence on risk, recurrence, metastasis and survival outcome in colorectal cancer

  Analysis Number of studies Se (95%CI) Sp (95%CI) AUC (95%CI)
Individual Ethnicity
   Asian 7 0.72 (0.65–0.79) 0.82 (0.73–0.89) 0.83 (0.79–0.86)
  Sample type
   Plasma 4 0.55 (0.38–0.70) 0.83 (0.72–0.91) 0.79 (0.75–0.83)
   Serum 4 0.73 (0.61–0.82) 0.78 (0.51–0.92) 0.79 (0.76–0.83)
   Circulating 8 0.65 (0.52–0.76) 0.82 (0.70–0.90) 0.80 (0.76–0.83)
   Feces 1 0.85 (0.73–0.93) 0.61 (0.49–0.71) 0.78 (0.69–0.86)
   Tissue 1 0.82 (0.75–0.87) 0.85 (0.81–0.88) 0.88
  Sample size
   > Median 5 0.61 (0.45–0.76) 0.86 (0.77–0.92) 0.84 (0.81–0.87)
   < Median 5 0.78 (0.68–0.85) 0.73 (0.54–0.86) 0.82 (0.79–0.85)
  miRNA profiling
   miR-29a 7 0.68 (0.52–0.81) 0.83 (0.67–0.92) 0.82 (0.79–0.85)
   miR-29b 3 0.72 (0.68–0.77) 0.77 (0.76–0.81) 0.86 (0.78–0.94)
  Overall 10 0.70 (0.58–0.79) 0.81 (0.71–0.88) 0.82 (0.79–0.85)
  Outliers excluded 8 0.72 (0.65–0.78) 0.82 (0.74–0.88) 0.82 (0.79–0.85)
Combination Overall 6 0.78 (0.73–0.82) 0.91 (0.83–0.95) 0.86 (0.83–0.89)
  1. AUC area under the curve, Se sensitivity, Sp specificity, 95% CI 95% confidence interval