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Table 4 Pooled results of diagnostic accuracy of miR-29 and combination biomarkers in CRC

From: Integrated analyses of microRNA-29 family and the related combination biomarkers demonstrate their widespread influence on risk, recurrence, metastasis and survival outcome in colorectal cancer

 

Analysis

Number of studies

Se (95%CI)

Sp (95%CI)

AUC (95%CI)

Individual

Ethnicity

 

 Asian

7

0.72 (0.65–0.79)

0.82 (0.73–0.89)

0.83 (0.79–0.86)

 

Sample type

 

 Plasma

4

0.55 (0.38–0.70)

0.83 (0.72–0.91)

0.79 (0.75–0.83)

 

 Serum

4

0.73 (0.61–0.82)

0.78 (0.51–0.92)

0.79 (0.76–0.83)

 

 Circulating

8

0.65 (0.52–0.76)

0.82 (0.70–0.90)

0.80 (0.76–0.83)

 

 Feces

1

0.85 (0.73–0.93)

0.61 (0.49–0.71)

0.78 (0.69–0.86)

 

 Tissue

1

0.82 (0.75–0.87)

0.85 (0.81–0.88)

0.88

 

Sample size

 

 > Median

5

0.61 (0.45–0.76)

0.86 (0.77–0.92)

0.84 (0.81–0.87)

 

 < Median

5

0.78 (0.68–0.85)

0.73 (0.54–0.86)

0.82 (0.79–0.85)

 

miRNA profiling

 

 miR-29a

7

0.68 (0.52–0.81)

0.83 (0.67–0.92)

0.82 (0.79–0.85)

 

 miR-29b

3

0.72 (0.68–0.77)

0.77 (0.76–0.81)

0.86 (0.78–0.94)

 

Overall

10

0.70 (0.58–0.79)

0.81 (0.71–0.88)

0.82 (0.79–0.85)

 

Outliers excluded

8

0.72 (0.65–0.78)

0.82 (0.74–0.88)

0.82 (0.79–0.85)

Combination

Overall

6

0.78 (0.73–0.82)

0.91 (0.83–0.95)

0.86 (0.83–0.89)

  1. AUC area under the curve, Se sensitivity, Sp specificity, 95% CI 95% confidence interval