Fig. 4

ANGPTL2 level is positively correlated with cell proliferation and migration/invasion in thyroid cancer. a Gene signatures for cell proliferation (GO_POSITIVE_REGULATION_OF_EPITHELIAL_CELL_PROLIFERATION and GO_REGULATION_OF_EPITHELIAL_CELL_PROLIFERATION) were enriched in a subgroup with higher ANGPTL2 expression. b The gene signature for cell migration (GO_POSITIVE_REGULATION_OF_EPITHELIAL_CELL_MIGRATION and GO_REGULATION_OF_EPITHELIAL_CELL_MIGRATION) was enriched in a subgroup with higher ANGPTL2 expression. c The gene signature for cell invasion (ANASTASSIOU_MULTICANCER_INVASIVENESS_SIGNATURE) was enriched in a subgroup with higher ANGPTL2 expression. Data were obtained from the TCGA dataset. False discovery rate (FDR) provides the estimated probability that a gene set with a given normalized ES (NES) represents a false-positive finding; FDR < 0.25 is an accepted cutoff for the identification of biologically significant gene sets