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Fig. 6 | Cancer Cell International

Fig. 6

From: lncRNA XIST regulates proliferation and migration of hepatocellular carcinoma cells by acting as miR-497-5p molecular sponge and targeting PDCD4

Fig. 6

lncRNAXIST regulated the proliferation and migration of HCC cells via the miR-497-5p-PDCD4 axis. a The effects of lncRAXIST overexpression on Huh7 and HepG2 cells by CCK-8 assay. b lncRNAXIST overexpression inhibited the migration of Huh7 and HepG2 cells. c, d lncRNAXIST overexpression increased PDCD4 mRNA and protein expression in Huh7 and HepG2 cells. e, f The miR-497-5p mimic rescued XIST overexpression -induced suppression of proliferation and migration in both Huh7 and HepG2 cells. g Overexpression of PDCD4 induced by XIST-mimic could be rescued by miR-497-5p overexpression. Error bars represent the mean ± SD from three independent experiments. *p < 0.05. IHC immunohistochemistry, NC negative control

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Cancer Cell International

ISSN: 1475-2867

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