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Fig. 7 | Cancer Cell International

Fig. 7

From: lncRNA XIST regulates proliferation and migration of hepatocellular carcinoma cells by acting as miR-497-5p molecular sponge and targeting PDCD4

Fig. 7

Overexpression of lncRNAXIST inhibited tumor growth in vivo. a The xenograft tumors were obviously inhibited by lncRNAXIST. b, c Tumor volume and tumor weight of the xenografts were significantly suppressed by lncRNAXIST-mimic. d lncRNAXIST-mimic upregulated PDCD4 expression in vivo by western blot analysis. e The expression of PDCD4 and Ki67 in the xenograft tumors was examined by IHC. Error bars represent the mean ± SD from three independent experiments. f Terminal deoxynucleotidyl transferased UTP nick end labeling (TUNEL) of specific tumor tissues at 21 days post-treatment. Green fluorescence indicated TUNEL-positive apoptotic cells; blue fluorescence indicated DAPI-stained nuclei. **p < 0.01. IHC immunohistochemistry, NC negative control, Mut mutated, UTR untranslated region, WT wild type

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