lncRNA XIST regulates proliferation and migration of hepatocellular carcinoma cells by acting as miR-497-5p molecular sponge and targeting PDCD4

Table 2 Univariate and multivariate Cox regression analyses of risk factors associated with overall survival

Variables	Univariate analysis			Multivariate analysis
Variables	HR	95% CI	p-value	HR	95% CI	p-value
miR-497-5p expression (low vs. high)	4.603	1.914–9.465	0.001	4.116	1.542–8.767	0.005
Gender (male vs. female)	0.656	0.325–1.326	0.241
Age (< 50 vs. ≥ 55)	0.609	0.370–1.005	0.052
HBsAg (negative vs. positive)	0.918	0.481–1.753	0.796
Cirrhosis (yes vs. no)	1.435	0.886–2.325	0.142
AFP (< 200 ng/mL vs. ≥ 200 ng/mL)	1.766	1.092–2.857	0.020	1.548	0.924–2.592	0.097
Tumor size (< 5 cm vs. ≥ 5 cm)	1.651	1.007–2.707	0.047	0.718	0.387–1.331	0.293
Tumor number (single vs. multiple)	2.184	1.296–3.680	0.003	1.105	0.585–2.088	0.758
PVTT (no vs. yes)	3.487	1.852–6.564	0.001	1.229	0.537–2.816	0.626
TNM stage (I/II vs. III/IV)	3.331	1.989–5.578	0.001	2.401	0.791–2.285	0.171
Edmondson grade (I/II vs. > II)	4.384	2.561–7.505	0.001	2.768	1.206–6.352	0.016

AFP alpha-fetoprotein determination, PVTT portal vein tumor thrombus, HBsAg hepatitis B virus, TNM tumor node metastasis, HR hazard ratio, CI confidence interval

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