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Table 2 Univariate and multivariate Cox regression analyses of risk factors associated with overall survival

From: lncRNA XIST regulates proliferation and migration of hepatocellular carcinoma cells by acting as miR-497-5p molecular sponge and targeting PDCD4

VariablesUnivariate analysisMultivariate analysis
HR95% CIp-valueHR95% CIp-value
miR-497-5p expression (low vs. high)4.6031.914–9.4650.0014.1161.542–8.7670.005
Gender (male vs. female)0.6560.325–1.3260.241   
Age (< 50 vs. ≥ 55)0.6090.370–1.0050.052   
HBsAg (negative vs. positive)0.9180.481–1.7530.796   
Cirrhosis (yes vs. no)1.4350.886–2.3250.142   
AFP (< 200 ng/mL vs. ≥ 200 ng/mL)1.7661.092–2.8570.0201.5480.924–2.5920.097
Tumor size (< 5 cm vs. ≥ 5 cm)1.6511.007–2.7070.0470.7180.387–1.3310.293
Tumor number (single vs. multiple)2.1841.296–3.6800.0031.1050.585–2.0880.758
PVTT (no vs. yes)3.4871.852–6.5640.0011.2290.537–2.8160.626
TNM stage (I/II vs. III/IV)3.3311.989–5.5780.0012.4010.791–2.2850.171
Edmondson grade (I/II vs. > II)4.3842.561–7.5050.0012.7681.206–6.3520.016
  1. AFP alpha-fetoprotein determination, PVTT portal vein tumor thrombus, HBsAg hepatitis B virus, TNM tumor node metastasis, HR hazard ratio, CI confidence interval