lncRNA XIST regulates proliferation and migration of hepatocellular carcinoma cells by acting as miR-497-5p molecular sponge and targeting PDCD4

Table 3 Univariate and multivariate Cox regression analyses of risk factors associated with disease-free survival

Variables	Univariate analysis			Multivariate analysis
Variables	HR	95% CI	p-value	HR	95% CI	p-value
miR-497-5p expression (high vs. low)	3.358	1.516–7.408	0.001	3.197	1.264–6.121	0.004
Gender (male vs. female)	0.379	0.116–1.237	0.108
Age (< 50 vs. ≥ 55)	0.501	0.246–1.024	0.058
HBsAg (negative vs. positive)	1.104	0.429–2.838	0.838
Cirrhosis (no vs. yes)	2.181	1.092–4.355	0.027	1.065	0.455–2.497	0.884
AFP (< 200 ng/mL vs. ≥ 200 ng/mL)	2.311	1.182–4.518	0.014	0.951	0.371–2.135	0.616
Tumor size (< 5 cm vs. ≥ 5 cm)	3.523	1.595–7.782	0.002	1.584	0.591–4.245	0.360
Tumor number (single vs. multiple)	1.652	0.818–3.337	0.162
PVTT (no vs. yes)	3.971	1.798–8.768	0.001	1.651	0.759–3.590	0.206
TNM stage (I/II vs. III/IV)	2.945	1.511–5.739	0.002	1.570	0.609–4.046	0.351
Edmondson grade (I/II vs. > II)	3.384	1.419–9.660	< 0.01	5.442	2.778–9.714	0.001

AFP alpha-fetoprotein determination, PVTT portal vein tumor thrombus, HBsAg hepatitis B surface antigen, TNM tumor node metastasis, HR hazard ratio, CI confidence interval

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