Skip to main content


Table 3 Univariate and multivariate Cox regression analyses of risk factors associated with disease-free survival

From: lncRNA XIST regulates proliferation and migration of hepatocellular carcinoma cells by acting as miR-497-5p molecular sponge and targeting PDCD4

VariablesUnivariate analysisMultivariate analysis
HR95% CIp-valueHR95% CIp-value
miR-497-5p expression (high vs. low)3.3581.516–7.4080.0013.1971.264–6.1210.004
Gender (male vs. female)0.3790.116–1.2370.108   
Age (< 50 vs. ≥ 55)0.5010.246–1.0240.058   
HBsAg (negative vs. positive)1.1040.429–2.8380.838   
Cirrhosis (no vs. yes)2.1811.092–4.3550.0271.0650.455–2.4970.884
AFP (< 200 ng/mL vs. ≥ 200 ng/mL)2.3111.182–4.5180.0140.9510.371–2.1350.616
Tumor size (< 5 cm vs. ≥ 5 cm)3.5231.595–7.7820.0021.5840.591–4.2450.360
Tumor number (single vs. multiple)1.6520.818–3.3370.162   
PVTT (no vs. yes)3.9711.798–8.7680.0011.6510.759–3.5900.206
TNM stage (I/II vs. III/IV)2.9451.511–5.7390.0021.5700.609–4.0460.351
Edmondson grade (I/II vs. > II)3.3841.419–9.660< 0.015.4422.778–9.7140.001
  1. AFP alpha-fetoprotein determination, PVTT portal vein tumor thrombus, HBsAg hepatitis B surface antigen, TNM tumor node metastasis, HR hazard ratio, CI confidence interval