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Table 1 Evaluation of p53 gene expression in MCF-7 cells

From: Modulation of doxorubicin-induced expression of the multidrug resistance gene in breast cancer cells by diltiazem and protection against cardiotoxicity in experimental animals

Treatment

Relative expression of p53

DIL 20 µg/ml

1.06 ± 0.65

DOX 0.25 µg/ml

1.20 ± 0.64

DOX 0.25 µg/ml + DIL 20 µg/ml

1.71 ± 1.4

DOX 1 µg/ml

1.43 ± 1.5

DOX 1 µg/ml + DIL 20 µg/ml

2.21 ± 1.1a

  1. Relative p53 mRNA gene expression level by RT-qPCR in MCF-7 cells that were treated with DOX/and or DIL for 48 h. The values represent the mean ± SD
  2. aSignificantly different from corresponding DOX at p-value < 0.05 (the delta–delta CT method)
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Cancer Cell International

ISSN: 1475-2867

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