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Table 1 Evaluation of p53 gene expression in MCF-7 cells

From: Modulation of doxorubicin-induced expression of the multidrug resistance gene in breast cancer cells by diltiazem and protection against cardiotoxicity in experimental animals

Treatment Relative expression of p53
DIL 20 µg/ml 1.06 ± 0.65
DOX 0.25 µg/ml 1.20 ± 0.64
DOX 0.25 µg/ml + DIL 20 µg/ml 1.71 ± 1.4
DOX 1 µg/ml 1.43 ± 1.5
DOX 1 µg/ml + DIL 20 µg/ml 2.21 ± 1.1a
  1. Relative p53 mRNA gene expression level by RT-qPCR in MCF-7 cells that were treated with DOX/and or DIL for 48 h. The values represent the mean ± SD
  2. aSignificantly different from corresponding DOX at p-value < 0.05 (the delta–delta CT method)