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Table 2 Effect of DOX and/or DIL on serum CK-MB level

From: Modulation of doxorubicin-induced expression of the multidrug resistance gene in breast cancer cells by diltiazem and protection against cardiotoxicity in experimental animals

Treatment CK-MB (pg/ml)
(48 h) (72 h)
Control 103 ± 14 112 ± 11
DIL (4 mg/kg i.p.) 100 ± 10 104 ± 21
DOX (15 mg/kg, i.p.) 690 ± 38a 659 ± 48a
DOX + DIL (administrated simultaneously) 367 ± 87b 348 ± 19b
  1. Data are expressed as mean ± SD of experiment in male Wistar rats after 48 h and 72 h (n = 2)
  2. aSignificantly different from control at p-value < 0.05
  3. bSignificantly different from corresponding DOX at p-value < 0.05