Modulation of doxorubicin-induced expression of the multidrug resistance gene in breast cancer cells by diltiazem and protection against cardiotoxicity in experimental animals

Table 2 Effect of DOX and/or DIL on serum CK-MB level

Treatment	CK-MB (pg/ml)
Treatment	(48 h)	(72 h)
Control	103 ± 14	112 ± 11
DIL (4 mg/kg i.p.)	100 ± 10	104 ± 21
DOX (15 mg/kg, i.p.)	690 ± 38^a	659 ± 48^a
DOX + DIL (administrated simultaneously)	367 ± 87^b	348 ± 19^b

Data are expressed as mean ± SD of experiment in male Wistar rats after 48 h and 72 h (n = 2)
^aSignificantly different from control at p-value < 0.05
^bSignificantly different from corresponding DOX at p-value < 0.05

ISSN: 1475-2867