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Table 3 Effect of DOX and/or DIL on MDA level

From: Modulation of doxorubicin-induced expression of the multidrug resistance gene in breast cancer cells by diltiazem and protection against cardiotoxicity in experimental animals

Treatment MDA (ng/ml)
(48 h) (72 h)
Control 53 ± 17 52 ± 4
DIL (4 mg/kg i.p.) 74 ± 16 73 ± 6
DOX (15 mg/kg, i.p.) 138 ± 21a 152 ± 31a
DOX + DIL (administrated simultaneously) 76 ± 42b 99 ± 2b
  1. Data are expressed as mean ± SD of experiment in male Wistar rats after 48 h and 72 h (n = 2)
  2. aSignificantly different from control at p-value < 0.05
  3. bSignificantly different from corresponding DOX at p-value < 0.05