Modulation of doxorubicin-induced expression of the multidrug resistance gene in breast cancer cells by diltiazem and protection against cardiotoxicity in experimental animals

Table 3 Effect of DOX and/or DIL on MDA level

Treatment	MDA (ng/ml)
Treatment	(48 h)	(72 h)
Control	53 ± 17	52 ± 4
DIL (4 mg/kg i.p.)	74 ± 16	73 ± 6
DOX (15 mg/kg, i.p.)	138 ± 21^a	152 ± 31^a
DOX + DIL (administrated simultaneously)	76 ± 42^b	99 ± 2^b

Data are expressed as mean ± SD of experiment in male Wistar rats after 48 h and 72 h (n = 2)
^aSignificantly different from control at p-value < 0.05
^bSignificantly different from corresponding DOX at p-value < 0.05

ISSN: 1475-2867