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Table 5 Effect of DOX and/or DIL on serum GPx level

From: Modulation of doxorubicin-induced expression of the multidrug resistance gene in breast cancer cells by diltiazem and protection against cardiotoxicity in experimental animals

Treatment Glutathione peroxidase (U/ml)
(48 h) (72 h)
Control 9.6 ± 0.48 9.7 ± 0.72
DIL (4 mg/kg i.p.) 9.8 ± 0.72 10.1 ± 0.46
DOX (15 mg/kg, i.p.) 5.4 ± 0.33a 4.8 ± 0.91a
DOX + DIL (administrated simultaneously) 9.4 ± 0.86b 9.5 ± 0.42b
  1. Data are expressed as mean ± SD of 2 experiments in male Wistar rats after 48 h and 72 h
  2. aSignificantly different from corresponding control at p-value < 0.05
  3. bSignificantly different from corresponding DOX at p-value < 0.05