Modulation of doxorubicin-induced expression of the multidrug resistance gene in breast cancer cells by diltiazem and protection against cardiotoxicity in experimental animals

Table 5 Effect of DOX and/or DIL on serum GPx level

Treatment	Glutathione peroxidase (U/ml)
Treatment	(48 h)	(72 h)
Control	9.6 ± 0.48	9.7 ± 0.72
DIL (4 mg/kg i.p.)	9.8 ± 0.72	10.1 ± 0.46
DOX (15 mg/kg, i.p.)	5.4 ± 0.33^a	4.8 ± 0.91^a
DOX + DIL (administrated simultaneously)	9.4 ± 0.86^b	9.5 ± 0.42^b

Data are expressed as mean ± SD of 2 experiments in male Wistar rats after 48 h and 72 h
^aSignificantly different from corresponding control at p-value < 0.05
^bSignificantly different from corresponding DOX at p-value < 0.05