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Fig. 4 | Cancer Cell International

Fig. 4

From: Long non-coding RNA MIAT promotes papillary thyroid cancer progression through upregulating LASP1

Fig. 4

MIAT directly binds miR-324-3p in papillary thyroid cancer cells. a Sequencing alignment showed that miR-324-3p harbored putative binding site for MIAT. b Through analysis of gene expression data in 509 papillary thyroid cancer tissues from TCGA, a negative correlation was observed between miR-324-3p levels and MIAT levels. c Transfection of miR-324-3p mimic increased miR-324-3p expression in HTH83 cells. d Overexpression of miR-324-3p reduced relative luciferase activity of MIAT-WT not MIAT-MUT in HTH83 cells. e Overexpression of miR-324-3p reduced relative luciferase activity of MIAT-WT not MIAT-MUT in BHT101 cells. f Overexpression of miR-324-3p reduced miR-324-3p levels in HTH83 and BHT101 cells. g Silencing of MIAT increased miR-324-3p levels in HTH83 and BHT101 cells. **p < 0.01; ***p < 0.001

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