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Fig. 3 | Cancer Cell International

Fig. 3

From: Mfn2 inhibits proliferation and cell-cycle in Hela cells via Ras-NF-κB signal pathway

Fig. 3

Mfn2 inhibited the tumor growth in vivo of cervical carcinoma mouse model and its signal pathway. a Determination of the tumor volume in mice treated with Adv-mfn2 or Adv-control for the 0, 3, 6 and 9 days. Data are represented as mean ± SD (**p < 0.01). b The sizes of xenografted cervix carcinoma after 14-days treatment in the Mfn2 group and the con group. c HE assay of tumor sections from animals treated with either Adv-control or Adv-Mfn2. Magnification: 200×. df The expression of Mfn2 and Cyclin D1 proteins in the tumors of mouse model was detected by western blot (a, b) and quantitation (c). Beta-actin was used as reference. Data are represented as mean ± SD (**p < 0.01). g Western blot showed Ras, Erk1/2 and Myc proteins expressions in cervix tumors treated with Adv-mfn2 after 2-weeks treatment. Total tumor tissue lysates were prepared and analyzed by Western blot for these proteins. GAPDH was used as reference. h Western blot showed mTOR and NF-κB proteins expressions in cervix tumors treated with Adv-mfn2 after 2-weeks treatment. Total tumor tissue lysates were prepared and analyzed by Western blot for these proteins. GAPDH was used as reference

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