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Fig. 4 | Cancer Cell International

Fig. 4

From: LPAR1 regulates the development of intratumoral heterogeneity in ovarian serous cystadenocarcinoma by activating the PI3K/AKT signaling pathway

Fig. 4

Role of LPAR1 in tumor formation in vivo. Xenograft experiments were performed to test and verify the role of LPAR1 in tumor formation. a Compared with the corresponding control groups, the tumors in the A-Lv-shLPAR1 and S-Lv-shLPAR1 groups were significantly smaller in terms of both volume (P < 0.001/= 0.001) and weight (both P < 0.001). In contrast, the tumors in the A-L1-LPAR1 and S-L1-LPAR1 groups were much larger than in the corresponding control groups in terms of both volume (both P < 0.001) and weight (both P < 0.001). In addition, no difference was observed between the control groups and the corresponding wild-type (WT) groups (all P > 0.05). b The tumor tissues were fixed formalin, embedded in paraffin, and stained with H&E. IHC were performed to detect LPAR1 expression. LPAR1 expression was detected using IHC, which verified the efficiency of the transduction with the lentiviral particles

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