Fig. 1

LC3B is upregulated in a chemoresistant group of EOC. a The LC3, Beclin1, caspase 3 and caspase 9 level in EOC ascites were measured by ELISA. n = 116 (no chemotherapy group: n = 64, sensitive group: n = 30 and resistant group: n = 22), *p < 0.05, **p < 0.01. b The level of LC3B, Beclin1, MDR1, cleaved-caspase 3 and caspase 9 expression in the EOC samples was measured by western blotting assay. c, d The level of LC3B, Beclin1, caspase 3 and caspase 9 expression in the EOC samples was measured by qRT-PCR assay. *p < 0.05, **p < 0.01, ***p < 0.001. e The MDR1 expression level in EOC samples was measured by qRT-PCR assay. *p < 0.05, **p < 0.01, ***p < 0.001. f The correlation between MDR1 level and LC3B in EOC tumor tissues/ascites cells was determined using Spearman correlation coefficients