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Fig. 5 | Cancer Cell International

Fig. 5

From: Inhibition LC3B can increase chemosensitivity of ovarian cancer cells

Fig. 5

Inhibit LC3B could promote apoptosis in vivo. a Schematic diagram of drug injection after the establishment of an abdominal cavity model of nude mouse ovarian cancer. b Representative images of the Bruker imaging system tracking the tumor process in vivo. c H&E staining. Green arrow shows apoptotic cells, red arrow shows inflammatory cells, and black arrow shows tumor cells. Scale bars: 10 µm. d Western blotting and statistical analysis were used to detect the expression of LC3B, Beclin1, MDR1, cleaved-caspase 3, caspase 6, caspase 9, P110, MMP2 and MMP9 in tumor tissue. e Dual fluorescence of LC3B and LAMP2 detection of autophagy expression in tumor tissue, LAMP2 (red), LC3B (green), DAPI (blue), co-localization (yellow). Scale bars: 10 µm. f TUNEL assay. Apoptosis cell (green), DAPI (blue). Scale bars: 10 µm

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