Fig. 5

ALDOA restoration reverses the suppression of cell proliferation and invasion mediated by DIO3OS knockdown or miR-122 overexpression. a, b Cell proliferation (a) and invasion (b) was assessed in MIA PaCa-2 cells transfected with DIO3OS siRNA or control siRNA, together with (or without) ALDOA vector. c, d Cell proliferation (c) and invasion (d) was assessed in MIA PaCa-2 cells transfected with miR-122 mimic or control mimic, together with (or without) ALDOA vector. e, f AsPC-1 cells were transfected with DIO3OS vector or control vector, together with (or without) ALDOA siRNA, and cell proliferation (e) and invasion (f) were measured. g, h AsPC-1 cells were transfected with miR-122 inhibitor or control inhibitor, together with (or without) ALDOA siRNA, and cell proliferation (g) and invasion (h) were measured. *P < 0.05