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Fig. 6 | Cancer Cell International

Fig. 6

From: miR-450b-5p loss mediated KIF26B activation promoted hepatocellular carcinoma progression by activating PI3K/AKT pathway

Fig. 6

KIF26B is targeting regulated by miR-450b-5p in HCC cells. a miR-450b-5p could be specific complementary pairing with 3′UTR sequence of KIF26B. b, c Expression difference of miR-450b-5p between HCC tissues and adjacent non-tumor tissues in our hospital HCC cohort and TCGA HCC cohort. d, e Protein and mRNA change of KIF26B in HCC cells under treatment of miR-450b-5p mimics, inhibitor and negative control. f Relative luciferase activity between KIF26B wild type and mutant type based on a dual-luciferase reporter assay. Values represent the mean ± SD (n = 5, each). g Relationship between KIF26B expression and miR-450b-5p expression in HCC tissues. *p < 0.05

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