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Fig. 1 | Cancer Cell International

Fig. 1

From: Upregulation of circFLNA contributes to laryngeal squamous cell carcinoma migration by circFLNA–miR-486-3p-FLNA axis

Fig. 1

circFLNA is upregulated in LSCC tissues and correlates with lymph node metastasis. a PCR was used to detect circFLNA in LSCC tissues by using convergent or divergent primers. Divergent primers amplify circFLNA in cDNA but not in genomic DNA (gDNA). GAPDH was used as linear control. b Hematoxylin and eosin staining of normal laryngeal tissues and LSCC tissues. c circFLNA expression in LSCC tissues (n = 39) and adjacent normal tissues (n = 39) detected by qRT-PCR analysis. Normalized to GAPDH. **P < 0.01 vs. adjacent normal tissues. d LSCC patients divided into two groups, with lymph node metastasis group or without lymph node metastasis group. qRT-PCR detected the expression of circFLNA in two groups. *P < 0.05 vs. group without lymph node metastasis. e qRT-PCR analysis detected the expression of circFLNA in four LSCC cell lines (SCC-2, SCC-20, Hep2 and Tu212) compared with human oral keratinocyte cell line HOK. *P < 0.05 vs. HOK cell

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