Skip to main content

Advertisement

Fig. 7 | Cancer Cell International

Fig. 7

From: Upregulation of circFLNA contributes to laryngeal squamous cell carcinoma migration by circFLNA–miR-486-3p-FLNA axis

Fig. 7

circFLNA/miR-486-3p/FLNA pathway regulates LSCC cell migration. a Hep2 cells were transfected with sh-FLNA or miR-486-3p mimic, respectively, or co-transfected with them together. Western blot analysis was used to determine MMP-2 and FLNA protein level. Right panel shows densitometric analysis. **P < 0.01, ***P < 0.001 vs. corresponding control. b Hep2 cells were treated as a, cell migration was evaluated by transwell assay. Bottom panel shows migration cell numbers *P < 0.05 vs. corresponding control. c Hep2 cells were transfected with pcDNA3.1-circFLNA or miR-486-3p mimic, respectively, or co-transfected with them together. MMP-2 and FLNA protein level was detected by western blot analysis. Right panel shows densitometric analysis.* P < 0.05, **P < 0.01, ***P < 0.001 vs. corresponding control. d Hep2 cells were prepared as c, cell migration was evaluated by transwell migration assay. Bottom panel shows migration cell numbers analysis of three independent experiments *P < 0.05 vs. corresponding control

Back to article page