Skip to main content
Fig. 1 | Cancer Cell International

Fig. 1

From: Long non-coding RNA LINC00485 acts as a microRNA-195 sponge to regulate the chemotherapy sensitivity of lung adenocarcinoma cells to cisplatin by regulating CHEK1

Fig. 1

LINC00485 specifically binds to miR-195, and miR-195 targets CHEK1. a The expression of CHEK1 in LAC and normal control in TCGA database; b the survival of CHEK1 in LAC; c the miRNAs that targeted CHEK1 predicted by 5 biological online sites; d the expression of miRNAs in LAC and normal tissues in TCGA database; e the expression of LINC00485 in LAC and normal tissues in TCGA database; f the binding sites of LINC00485 and miR-195; g the luciferase activity of LINC00485-Wt and LINC00485-Mut without or with transfection of miR-195; h the binding sites of miR-195 and CHEK1; i luciferase activity of CHEK1-Wt and CHEK1-Mut without or with transfection of miR-195; *p < 0.05 vs. the NC. The enumeration data between two groups were analyzed by t test. All the experiments were detected 3 times independently, and the results were expressed as mean ± standard deviation. LINC00485, long intervening noncoding 00485; CHEK1, checkpoint kinase 1; Wt, wide type; Mut, mutant type; LAC, lung adenocarcinoma; TCGA, the Cancer Genome Atlas

Back to article page

Cancer Cell International

ISSN: 1475-2867

Contact us