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Fig. 7 | Cancer Cell International

Fig. 7

From: Long non-coding RNA LINC00485 acts as a microRNA-195 sponge to regulate the chemotherapy sensitivity of lung adenocarcinoma cells to cisplatin by regulating CHEK1

Fig. 7

Up-regulated miR-195 or down-regulated LINC00485 promotes the apoptosis of LAC cells treated with cisplatin. a The apoptosis rate of A549 cells with intervention of LINC00485; b the apoptosis of A549 cells treated by 3 μg/mL cisplatin with intervention of LINC00485; c the apoptosis rate of A549 cells with miR-195 intervention; d the apoptosis of A549 cells treated by 3 μg/mL cisplatin with intervention of miR-195; e the apoptosis rate of A549 cells with intervention of CHEK1; f the apoptosis of A549 cells treated by 3 μg/mL cisplatin with intervention of CHEK1; g the apoptosis rate of H1299 cells with intervention of LINC00485; h the apoptosis of H1299 cells treated by 3 μg/mL cisplatin with intervention of LINC00485; i the apoptosis rate of H1299 cells with intervention of miR-195; j the apoptosis of H1299 cells treated by 3 μg/mL cisplatin with intervention of miR-195; k the apoptosis rate of H1299 cells with intervention of CHEK1; l the apoptosis of H1299 cells treated by 3 μg/mL cisplatin with intervention of CHEK1; *p < 0.05 vs. the control; #p < 0.05 vs. cells transfected with blank vector, si-NC, NC and anta-Ctrl. Differences among multiple groups were analyzed by one-way ANOVA. All the experiments were detected 3 times independently, and the results were expressed as mean ± standard deviation

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Cancer Cell International

ISSN: 1475-2867

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