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Fig. 1 | Cancer Cell International

Fig. 1

From: Haploinsufficiency of NR3C1 drives glucocorticoid resistance in adult acute lymphoblastic leukemia cells by down-regulating the mitochondrial apoptosis axis, and is sensitive to Bcl-2 blockage

Fig. 1

Association between endogenous expression of NR3C1 in ALL cells and sensitivity to glucocorticoids and clinical treatment outcomes. a Effects of dexamethasone on human ALL cell proliferation. Shown are summarized results of cell viability assays in ALL cell lines treated with different concentrations (0.1, 0.5, 1.0, 2.5 or 5 μmol/l) of dexamethasone after 24–48 h. Statistical analyses compared cells treated with DMSO and those treated with the indicated drugs using t-tests (unpaired, two-sided). The data are presented as means of 3 replications. b RT-qPCR (left) and western blotting (right) analysis of endogenous NR3C1 expression in ALL cell lines. c Comparison of NR3C1 mRNA expression in bone marrow blast samples from patients of good responders to prednisolone (n = 19) and patients with refractory or relapsed ALL (n = 30). Error bars represent standard deviation (SD). *p < 0.05, **p < 0.01, ***p < 0.001

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