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Fig. 5 | Cancer Cell International

Fig. 5

From: Haploinsufficiency of NR3C1 drives glucocorticoid resistance in adult acute lymphoblastic leukemia cells by down-regulating the mitochondrial apoptosis axis, and is sensitive to Bcl-2 blockage

Fig. 5

Effects of Bcl-2 blockage in glucocorticoid-resistant ALL cells. a Results of cell viability assays in Reh and Jurkat ALL cell lines treated with different concentrations (1 or 5 μmol/l) of the Bcl-2 inhibitor ABT-263, dexamethasone, or dexamethasone plus ABT-263 for 24–48 h. b Results of apoptosis assays in Reh and Jurkat ALL cell lines treated with different concentrations (1 or 5 μmol/l) of the Bcl-2 inhibitor ABT-263, dexamethasone, or dexamethasone plus ABT-263 for 48 h. Statistical analyses compared cells treated with dexamethasone and those treated with ABT-263, dexamethasone plus ABT-263 using t-tests (unpaired, two-sided). The data are presented as means of 3 replications. *p < 0.05, **p < 0.01, ***p < 0.001

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Cancer Cell International

ISSN: 1475-2867

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