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Fig. 2 | Cancer Cell International

Fig. 2

From: Secretory leukocyte protease inhibitor suppresses HPV E6-expressing HNSCC progression by mediating NF-κB and Akt pathways

Fig. 2

E6 oncogene promotes the proliferation, migration, and invasion of HNSCC cells. a, b MTT experiment illustrated that E6 oncogene facilitated the proliferation of HNSCC cells. c, d Cell cycle assay demonstrated that E6 promoted cell growth by increasing the number of cells in S phase and decreasing cells in G1 phase. e Apoptosis assay results showed that E6 oncogene significantly resisted the apoptosis activities induced by DMSO in HNSCC cells. f Transwell migration assay revealed E6 oncogene facilitated the migration of HNSCC cells. g Transwell invasion assay illustrated E6 oncogene significantly elevated the invasive abilities of HNSCC cells. h, i E6 oncogene enhanced the migrating capacities of HNSCC cells, suggested by wound healing assay. The fields of migrated and invasive cells on the membrane were captured (magnification × 100). Statistical analysis was performed using the t-tests. The data represented the mean values of three independent experiments. *P < 0.05. **P < 0.01. ***P < 0.001

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