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Fig. 4 | Cancer Cell International

Fig. 4

From: MBD1 promotes the malignant behavior of gallbladder cancer cells and induces chemotherapeutic resistance to gemcitabine

Fig. 4

MBD1 induces EMT in GBC cancer cells and plays a role in the chemosensitivity of GBC cells. a MBD1 silencing resulted in increased expression of the epithelial marker E-cadherin and inhibition of mesenchymal markers, including Twist1, N-cadherin and Vimentin. bd GBC cell chemosensitivity to Gem was evaluated in MBD1 knockdown cell clones. b The Gem sensitivity of GBC-SD cells with downregulation of MBD1 expression was significantly enhanced relative to that of control cells. c MBD1 knockdown elevated the Gem sensitivity of SGC-996 cells relative to that of control cells. d Inhibition of MBD1 expression dramatically decreased the IC50 of Gem in GBC-SD and SGC-996 cells. *P < 0.05, **P < 0.01

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