Table 2 Univariate and multivariate analysis associated with OS and DFS (n = 304)
Variables | Overall survival | Disease-free survival | ||||
|---|---|---|---|---|---|---|
Univariate p value | Multivariable analysis | Univariate p value | Multivariable analysis | |||
HR (95% CI) | p value | HR (95% CI) | p value | |||
Age (years) | ||||||
 < 50 |  |  |  |  |  |  |
 ≥ 50 | 0.241 |  |  | 0.246 |  |  |
Gender | ||||||
 Female |  |  |  |  |  |  |
 Male | 0.965 |  |  | 0.352 |  |  |
HbsAg | ||||||
 No |  |  |  |  |  |  |
 Yes | 0.910 |  |  | 0.343 |  |  |
AFP (ng/ml) | ||||||
 < 400 |  |  |  |  |  |  |
 ≥ 400 | 0.079 |  | n.a. | 0.012 |  | n.a. |
Tumor size (cm) | ||||||
 < 5.0 |  |  |  |  |  |  |
 ≥ 5.0 | < 0.001 | 2.548 (1.799–3.607) | < 0.001 | < 0.001 | 2.417 (1.755–3.328) | < 0.001 |
Tumor number | ||||||
 Solitary |  |  |  |  |  |  |
 Multiple | < 0.001 | 1.532 (1.061–2.212) | 0.023 | < 0.001 | 1.509 (1.054–2.159) | 0.025 |
Microvascular invasion | ||||||
 No |  |  |  |  |  |  |
 Yes | < 0.001 | 3.160 (2.227–4.484) | < 0.001 | < 0.001 | 1.973 (1.415–2.751) | < 0.001 |
NAP1L1 expression | ||||||
 Low |  |  |  |  |  |  |
 High | < 0.001 | 1.958 (1.391–2.755) | < 0.001 | < 0.001 | 1.876 (1.373–2.565) | < 0.001 |