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Fig. 1 | Cancer Cell International

Fig. 1

From: LncRNA SNHG6 promotes chemoresistance through ULK1-induced autophagy by sponging miR-26a-5p in colorectal cancer cells

Fig. 1

SNHG6 enhances drug-resistance to 5-FU and reduces 5FU-induced cell apoptosis in CRC cells. a, b SNHG6 knockdown and overexpression in CRC cells. c, d SNHG6 knockdown CRC cells were more sensitive to 5-FU, with lower IC50. e, f SNHG6 overexpression CRC cells were more resistant to 5-FU, with higher IC50. g, h SNHG6 knockdown CRC cells increased 5FU-induced apoptosis. i, j SNHG6 overexpression CRC cells reduced 5FU-induced apoptosis. k Western blot analysis of apoptosis well-defined proteins showed that SNHG6 could reduce RKO cells apoptosis. ns P > 0.05, *P < 0.05, **P < 0.01, *** P < 0.001, ****P < 0.0001, data was shown as the mean ± SD

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