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Fig. 5 | Cancer Cell International

Fig. 5

From: LncRNA SNHG6 promotes chemoresistance through ULK1-induced autophagy by sponging miR-26a-5p in colorectal cancer cells

Fig. 5

Functional verification experiments confirm SNHG6 could regulate ULK1-induced autophagy via sponging miR-26a-5p. a–c 3-MA could reduce the difference of autophagy pathway proteins, IC50 and 5FU-induced apoptosis between RKO-shSNHG6 cells and RKO-Scramble cells. d miR-26a-5p inhibitors could bring back autophagy pathway proteins of RKO-shSNHG6 cells and overexpression of miR-26a-5p could decrease them in RKO-SNHG6 cells. e miR-26a-5p inhibitors could reduce RKO-shSNHG6 cells apoptosis but miR-26a-5p brought it back in RKO-SNHG6 cells. ns P > 0.05, *P < 0.05, **P < 0.01, ***P < 0.001, ****P < 0.0001, data was shown as the mean ± SD

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