Skip to main content
Fig. 1 | Cancer Cell International

Fig. 1

From: CDK5 neutralizes the tumor suppressing effect of BIN1 via mediating phosphorylation of c-MYC at Ser-62 site in NSCLC

Fig. 1

The expression of CDK5 and its effect on the BIN1/c-MYC interaction in NSCLC cells. a The protein expression of BIN1 and CDK5 in NSCLC cell lines and embryo lung cells 2BS detected by western blotting. b The co-expression status of CDK5 and BIN1 in H460 and PC9 cells detected by immunofluorescence. c The efficiency of various siRNAs in suppressing the expression of CDK5. d The effect of CDK5 knockdown on the expression of CDK5, c-MYC and phosphorylated c-MYC at Ser-62 site in H460 cells. e The effect of CDK5 overexpression on the expression of CDK5, c-MYC and phosphorylated c-MYC at Ser-62 site in PC9 cells. f The effect of CDK5 on the interaction of BIN1/c-MYC in H460 and PC9 cells detected with Co-IP. Significant P-values marked by asterisk: *P < 0.05

Back to article page

Cancer Cell International

ISSN: 1475-2867

Contact us