Fig. 2

Schematic of the proposed effect of CDK5 on the interaction between BIN1 and c-MYC. a BIN1 could bind to the N terminus of c-MYC with its SH3 domain to inhibit the proliferation, migration and invasion ability of NSCLC cells. b CDK5 could induce the phosphorylation of c-MYC at Ser-62 site. Thus, the presence of CDK5 could block the interaction between BIN1 and c-MYC to neutralize the tumor-suppressing effect of BIN1