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Fig. 4 | Cancer Cell International

Fig. 4

From: CDK5 neutralizes the tumor suppressing effect of BIN1 via mediating phosphorylation of c-MYC at Ser-62 site in NSCLC

Fig. 4

The effect of Dinaciclib treatment on H460 cells in vitro and in vivo. a The effects of Dinaciclib (concentration: 1 nM) on the expression of CDK5 and its activated form CDK5/p35 in vitro. b The effects of Dinaciclib (concentration: 1 nM) on the expression of phosphorylated c-MYC at Ser-62 site, c-MYC and BIN1. c The effects of Dinaciclib on the BIN1/c-MYC interaction. d, e The tumor volume of nude mice bearing with H460 cells. Significant P-values marked by asterisk: *P < 0.05

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Cancer Cell International

ISSN: 1475-2867

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