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Table 2 Top ten terms of GO analysis for PD-1 and PD-L1

From: PD-1 and PD-L1 correlated gene expression profiles and their association with clinical outcomes of breast cancer

Gene

Description

GENERATIO

P value

P adjust

Count

PD1

T cell activation

54/161

8.67E−47

1.53E−43

54

Regulation of lymphocyte activation

43/161

8.13E−32

7.17E−29

43

Leukocyte cell–cell adhesion

37/161

9.69E−31

4.27E−28

37

Regulation of T cell activation

36/161

1.45E−30

5.11E−28

36

Antigen receptor-mediated signaling pathway

31/161

1.61E−26

4.74E−24

31

Regulation of leukocyte cell–cell adhesion

32/161

4.29E−26

1.08E−23

32

Regulation of mononuclear cell proliferation

25/161

1.22E−21

1.13E−19

25

Mononuclear cell proliferation

27/161

3.08E−21

2.59E−19

27

Leukocyte migration

28/161

1.13E−15

6.04E−14

28

Lymphocyte mediated immunity

23/161

3.15E−14

1.43E−12

23

Adaptive immune response

22/161

5.23E−13

2.15E−11

22

Regulation of leukocyte mediated immunity

16/161

1.61E−11

5.57E−10

16

PDL1

Cytolysis

4/38

1.18E−06

0.00130442

4

Aromatic amino acid family catabolic process

3/38

2.53E−05

0.01394493

3

T cell apoptotic process

3/38

0.00014677

0.02200257

3

Positive regulation of tolerance induction

2/38

0.0001831

0.02200257

2

Indole-containing compound catabolic process

2/38

0.0001831

0.02200257

2

Positive regulation of killing of cells of other organism

2/38

0.00026786

0.02200257

2

Natural killer cell mediated immunity

3/38

0.00027843

0.02200257

3

Cell killing

4/38

0.00030195

0.02200257

4

Positive regulation of cell killing

3/38

0.00030586

0.02200257

3

Regulation of leukocyte cell–cell adhesion

5/38

0.00031554

0.02200257

5

Regulation of killing of cells of other organism

2/38

0.00036836

0.02200257

2

Positive regulation of T cell apoptotic process

2/38

0.00036836

0.02200257

2