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Table 1 Characteristics of training, validation and meta-validation cohorts

From: A signature of hypoxia-related factors reveals functional dysregulation and robustly predicts clinical outcomes in stage I/II colorectal cancer patients

Characteristic TCGA CIT/GSE39582 Meta-validation
Number of patients 624 566 687
Patients with survival data 509 557 590
Mean age, years 66.27 ± 12.76 66.85 ± 13.29 66.80 ± 12.82
Gender, n
 Male 332 310 371
 Female 292 256 316
TNM stage, n
 Stage I 105 33 68
 Stage II 230 264 314
 Stage III 180 205 205
 Stage IV 88 60 100
 NA 21 4 0
CMS system, n
 CMS1 68 91 126
 CMS2 207 232 252
 CMS3 64 69 103
 CMS4 117 127 155
 NA 168 47 51
Tumor location, n
 Left 354 342 233
 Right 270 224 185
 NA    269
RFS event, n
 Yes 100 177 141
 No 416 380 449
 NA 108 9 97
OS event, n
 Yes 67 191 73
 No 557 371 104
 NA   4 220
DFS event, n
 Yes 146 248 188
 No 386 314 434
 NA 92 4 65
MMR status, n
 MSI 189 75 25
 MSS 431 444 65
 NA 4 47 597
CIMP status, n
 Positive   91 26
 Negative   405 64
 NA 624 70 597
CIN status, n
 Positive   353  
 Negative   110  
 NA 624 103 687
TP53 status, n
 Wild type   161  
 Mutation   190  
 NA 624 215 687
KRAS status, n
 Wild type 34 328 70
 Mutation 30 217 20
 NA 560 21 597
BRAF status, n
 Wild type 32 461 73
 Mutation 3 51 17
 NA 589 54 597