From: A signature of hypoxia-related factors reveals functional dysregulation and robustly predicts clinical outcomes in stage I/II colorectal cancer patients
Cohorts
HGS
Oncotype DX
C-index
95% CI
CIT/GSE39582 (training)
0.80
0.70–0.90
0.65
0.53–0.77
TCGA (validation)
0.70
0.55–0.85
0.61
0.44–0.77
Meta-validation
0.68
0.55–0.80
0.73
0.64–0.83