Fig. 1

Effects of PLA on HPV E6 and E7 expression and on the migration and invasion of cervical cancer cells. a,  b The transcriptional and translational levels of E6 and E7 in SiHa (a) and HeLa (b) cells treated with different concentrations of PLA (2.5, 5, 10, and 20 mM) for 24 h. GAPDH expression was evaluated as a loading control. One representative of three different experiments, for each of the analyses performed, is shown. c, d Effects of different concentrations of PLA (2.5, 5, 10, and 20 mM) on the migration (c) and invasion (d) of SiHa cells as determined by Transwell assay. e, f Effects of different concentrations of PLA (2.5, 5, 10, and 20 mM) on the migration (e) and invasion (f) of HeLa cells as determined by Transwell assay. g, h Effects of different concentrations of PLA (2.5, 5, 10, and 20 mM) on the migration (g) and invasion (h) of C-33A cells as determined by Transwell assay. Data are presented as the means ± SDs of three independent experiments. ^*P < 0.05, ^**P < 0.01, and ^***P < 0.001 compared with the control