Fig. 2

Dysregulated apoptosis and lung cancer. The anti-apoptotic and pro-apoptotic members of the Bcl-2 family undergo imbalance, which leads to dysregulated apoptosis. The overexpression of anti- apoptotic include group 1 (Bcl-2, Bcl-xL, Mcl-1, Bcl-w, A1/BF-1, BclB/Bcl2L10) and under expression of group 2 (Bim, Bid, Puma, Noxa, Bad, Hrk, Bik) and under expression of group 3 (Bak, Bax, and Bok/Mtd) resulted to dysregulated apoptosis and lung cancer. Other factors involved includes reduced expression of caspases, increased expression of inhibitor of apoptosis proteins, mutation on p53, impaired receptor signalling pathway and reduced expression of death receptor