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Table 1 Characteristics of Subsets of T cells (Treg)

From: CD146 T cells in lung cancer: its function, detection, and clinical implications as a biomarker and therapeutic target

Subset Specific marker Secretory products Actions Location
nTreg CD4, CD25, Foxp3 IL-10, TGF-β Block T cell proliferation, suppression of DCs, inhibition of effector Th1, Th2, and Th17 cells; suppress mast cells, basophils, and eosinophils; interact with resident tissue cells Thymus
nTeg CD4, CD25, CD127 IL-10, TGF-β Block T cell proliferation, Neonatal thymus
ICOS(+) Treg CD4, CD25, Foxp3, ICOS IL-10, IL-17, IFN-γ Suppress hapten-reactive CD8(+) T cells Generated from nTregs
iTreg CD4, Foxp3 IL-10, TGF-β Similar to nTreg Periphery
Tr1 CD4, CD25 IL-10 Suppress effector Th cell migration and functions suppress mast cells, basophils, and eosinophils Generated from non-Treg cell precursors and home lungs and draining lymph nodes
CD8(+)Treg CD8, Foxp3, CD25 (not for tonsil origin), CD28 IL-10, TNF-α, IFN-γ, GB Block activation of naive or effector T cells; suppress IgG/IgE antibody responses [9], IL-4 expression and the proliferation of CD4(+) T cells Generated from OT-1 CD8 cells [9] and tonsils
IL-17-producing Foxp3 (+) Treg CD4, Foxp3, CCR6, RORGTF IL-17 Inhibit the proliferation of CD4(+) effector T cells Differentiated from CD4(+)Foxp3(+)CCR6(−) Tregs in peripheral blood and lymphoid tissue
  1. nTreg natural regulatory T cell, ICOS inducible costimulator, iTreg inducible/adaptive regulatory T cell, Tr1 cell IL-10-producing type 1 regulatory T cell, GB granzyme B, RORGTF ROR gamma transcription factor