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Table 4 Summary of lncRNA NNT-AS1 with their potential targets, functional roles, signaling pathways, and related miRNAs

From: The prognostic value of long noncoding RNA SNHG16 on clinical outcomes in human cancers: a systematic review and meta-analysis

Tumor type Potential targets Functional roles Pathways Related miRNAs
Acute lymphoblastic leukemia Cell proliferation and migration   miR-124-3p
Bladder cancer STAT3 Cell invasion, migration and EMT miR-98
Bladder cancer P21 Cell proliferation
Breast cancer E2F5 Cell migration miR-98
Cervical cancer ZEB1 Cell invasion and migration miR-216-5p
Colorectal cancer   Cell migration and anti-apoptosis Wnt/β-catenin
Esophageal squamous
cell carcinoma
ZEB1 Cell proliferation, migration and EMT MiR-140-5P
Esophageal squamous
cell carcinoma
Cell proliferation Wnt/β-catenin
Glioma PRMT5, Bcl-2 Anti-apoptosis PI3 K/Akt miR-4518
Glioma E2F1 Cell proliferation and EMT miR-20a-5p
Hepatocellular carcinoma Anti-proliferation and anti-chemoresistance miR-93
Non-small cell lung cancer MUC5AC Cell proliferation and migration miR-146a
Osteosarcoma ZEB1 Cell proliferation miR-205
Oral squamous cell carcinoma PCNA, MMP-2, MMP-9 Cell proliferation, invasion and migration
Ovarian cancer p-Akt, MMP-9 Cell invasion and migration
  1. Akt protein kinase B, Bcl-2 B-cell lymphoma 2, E2F1 E2F transcription factor 1, E2F5 E2F transcription factor 5, EMT epithelial–mesenchymal transition, MMP-2 matrix metalloproteinase 2, MMP-9 matrix metalloproteinase 9, MUC5AC mucin 5AC, PI3 K phosphoinositide 3-kinase, PCNA proliferating cell nuclear antigen, p-Akt phosphorylated protein kinase B, PRMT5 protein arginine methyltransferase 5, STAT3 signal transducer and activator of transcription 3, ZEB1 zinc finger E-box-binding homeobox 1