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Table 4 Summary of lncRNA NNT-AS1 with their potential targets, functional roles, signaling pathways, and related miRNAs

From: The prognostic value of long noncoding RNA SNHG16 on clinical outcomes in human cancers: a systematic review and meta-analysis

Tumor type

Potential targets

Functional roles

Pathways

Related miRNAs

Acute lymphoblastic leukemia

–

Cell proliferation and migration

 

miR-124-3p

Bladder cancer

STAT3

Cell invasion, migration and EMT

–

miR-98

Bladder cancer

P21

Cell proliferation

–

–

Breast cancer

E2F5

Cell migration

–

miR-98

Cervical cancer

ZEB1

Cell invasion and migration

–

miR-216-5p

Colorectal cancer

 

Cell migration and anti-apoptosis

Wnt/β-catenin

–

Esophageal squamous

cell carcinoma

ZEB1

Cell proliferation, migration and EMT

–

MiR-140-5P

Esophageal squamous

cell carcinoma

–

Cell proliferation

Wnt/β-catenin

–

Glioma

PRMT5, Bcl-2

Anti-apoptosis

PI3 K/Akt

miR-4518

Glioma

E2F1

Cell proliferation and EMT

–

miR-20a-5p

Hepatocellular carcinoma

–

Anti-proliferation and anti-chemoresistance

–

miR-93

Non-small cell lung cancer

MUC5AC

Cell proliferation and migration

–

miR-146a

Osteosarcoma

ZEB1

Cell proliferation

–

miR-205

Oral squamous cell carcinoma

PCNA, MMP-2, MMP-9

Cell proliferation, invasion and migration

–

–

Ovarian cancer

p-Akt, MMP-9

Cell invasion and migration

–

–

  1. Akt protein kinase B, Bcl-2 B-cell lymphoma 2, E2F1 E2F transcription factor 1, E2F5 E2F transcription factor 5, EMT epithelial–mesenchymal transition, MMP-2 matrix metalloproteinase 2, MMP-9 matrix metalloproteinase 9, MUC5AC mucin 5AC, PI3 K phosphoinositide 3-kinase, PCNA proliferating cell nuclear antigen, p-Akt phosphorylated protein kinase B, PRMT5 protein arginine methyltransferase 5, STAT3 signal transducer and activator of transcription 3, ZEB1 zinc finger E-box-binding homeobox 1