Fig. 2

DNA hypomethylation, gain/amplification, MYC amplification and driver mutation of CTNNB1 was responsible for the deregulation of RUVBL2. a RUVBL2 mRNA expression was inversely correlated with DNA methylation status in liver cancer based on the TCGA RNA-sequencing and DNA methylation 450 k bead array datasets. Pearson correlation coefficients were calculated between the log2-transformed RPM values and methylation status of RUVBL2. b RUVBL2 mRNA expression showed gradient increase with the copy numbers of RUVBL2 gene. c The patients with MYC amplification had higher levels of RUVBL2 expression. No amp, no amplification; Amp, amplification. d RUVBL2 mRNA expression showed gradient increase with the copy numbers of MYC gene. For (b) and (d), values: − 2 = homozygous deletion; − 1 = hemizygous deletion; 0 = neutral/no change; 1 = gain; 2 = high-level amplification. e The patients with CTNNB1 mutation had higher levels of RUVBL2 expression. No mut, no mutation; Mut, mutation. f RUVBL2 mRNA expression was inversely correlated with the levels of CTNNB1 in liver cancer. Pearson correlation coefficients were calculated between the log2-transformed RPM values of both genes