From: Multilevel regulation of RUVBL2 expression predicts poor prognosis in hepatocellular carcinoma
Variables | Overall survival | Relapse-free survival | ||||
---|---|---|---|---|---|---|
P-value | HR | 95% CI | P-value | HR | 95% CI | |
Nuclear RUVBL2 (strong vs. Neg + weak) | 0.0064 | 2.03 | 1.22–3.37 | 0.1522 | 1.42 | 0.88–2.31 |
Cytoplasmic RUVBL2 (strong vs. Neg + weak) | 0.0862 | 1.47 | 0.95–2.27 | 0.0088 | 1.71 | 1.44–2.56 |
Age (> 60 vs. ≤ 60) | 0.7896 | 1.06 | 0.68–1.66 | 0.6266 | 1.11 | 0.73–1.67 |
Sex (female vs. male) | 0.2357 | 0.54 | 0.20–1.49 | 0.0713 | 0.40 | 0.15–1.08 |
Family history (yes vs. no) | 0.0943 | 0.66 | 0.41–1.07 | 0.0590 | 0.65 | 0.42–1.02 |
Symptom presentation (yes vs. no) | 0.0864 | 1.46 | 0.95–2.26 | 0.1258 | 1.36 | 0.92–2.03 |
Drinking (yes vs. no) | 0.7888 | 0.94 | 0.62–1.44 | 0.7493 | 0.94 | 0.65–1.37 |
HBsAg (positive vs. negative) | 0.1842 | 0.71 | 0.42–1.18 | 0.4802 | 0.84 | 0.51–1.37 |
Anti-HCV (positive vs. negative) | 0.5942 | 1.23 | 0.57–2.68 | 0.7104 | 1.15 | 0.56–2.37 |
Cirrhosis (moderate + severe vs. w/o + mild) | 0.0545 | 1.52 | 0.99–2.34 | 0.1645 | 1.32 | 1.89–1.96 |
CEA (> 5 vs. ≤ 5) | 0.3999 | 1.40 | 0.64–3.04 | 0.3377 | 1.40 | 0.70–2.78 |
ALP (aberrant vs. normal) | 0.9062 | 0.96 | 0.50–1.84 | 0.3606 | 1.29 | 0.75–2.24 |
AFP (> 20 vs. ≤ 20) | 0.6581 | 1.10 | 0.71–1.70 | 0.8061 | 1.05 | 0.71–1.56 |
Differentiation grade (poor vs. well + moderate) | 0.0363 | 1.30 | 1.02–1.66 | 0.0409 | 1.27 | 1.01–1.60 |
Tumor size (> 5 cm vs. ≤ 5 cm) | 0.0459 | 1.57 | 1.01–2.44 | 0.0107 | 1.69 | 1.13–2.53 |
Multinodules (yes vs. no) | 0.0853 | 1.56 | 0.94–2.58 | 0.1152 | 1.46 | 0.91–2.36 |
Tumor-infiltrating lymphocytes (yes vs. no) | 0.7268 | 1.09 | 0.67–1.76 | 0.4599 | 1.18 | 0.76–1.84 |
Liver capsule invasion (yes vs. no) | 0.4503 | 0.84 | 0.54–1.31 | 0.7892 | 0.95 | 0.63–1.42 |
Carcinoma cell embolus (yes vs. no) | 0.0080 | 2.19 | 1.23–3.90 | 0.0003 | 2.66 | 1.56–4.53 |
TNM staging (III + IV vs. I + II) | < 0.0001 | 1.65 | 1.25–2.19 | 0.0014 | 1.54 | 1.18–2.00 |
BCLC staging (2 + 3 vs. 0 + 1) | < 0.0001 | 2.45 | 1.49–4.04 | 0.0023 | 2.10 | 1.30–3.38 |