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Fig. 10 | Cancer Cell International

Fig. 10

From: Inactivation of the Wnt/β-catenin signaling pathway underlies inhibitory role of microRNA-129-5p in epithelial–mesenchymal transition and angiogenesis of prostate cancer by targeting ZIC2

Fig. 10

The molecular mechanism of miR-129-5p regulation of ZIC2 expression and the Wnt/β-catenin signaling pathway in PCa. In PCa, the expression of miR-129-5p was significantly decreased, while the expression of ZIC2 was significantly increased. miR-129-5p targeted ZIC2 and inhibited the expression of ZIC2. The up-regulated miR-129-5p could suppresses the expression of ZIC2, leading to reduced expression of Wnt, β-catenin, N-cadherin and vimentin with increase in E-cadherin expression. Eventually, up-regulated miR-129-5p significantly inhibited cell proliferation, migration, invasion and EMT while promoting PCa cell apoptosis

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Cancer Cell International

ISSN: 1475-2867

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