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Table 3 Comparison of the EGFR mutation status between tumor tissue and plasma in NSCLC patients (N=47)

From: Selecting short length nucleic acids localized in exosomes improves plasma EGFR mutation detection in NSCLC patients

EGFR genotype TP and TNa cfDNA Short-length exoTNA
Mutant type Wild-type Mutant type Wild-type
Mutant type 17 11 6 13 4
Wild-type 124 3 121 0 124
Sensitivity,% (95% CI)   64.7% (38.3–85.8%) 76.5% (50.1–93.2%)
Specificity, % (95% CI)   97.6% (93.1–99.5%) 100.0% (97.1–100.0%)
Accuracy, % (95% CI)   93.6% (88.2–97.0%) 97.2% (92.9–99.2%)
  1. NSCLC non-small cell lung cancer, TP true positive, TN true negative, CI confidence interval
  2. aTissue EGFR genotyping results were considered ‘true positive’ or ‘true negative.’ Three cases for which tissue EGFR was negative showed positive results using the cobas® EGFR Mutation Test v2. These results were regarded as ‘true positive.’