Selecting short length nucleic acids localized in exosomes improves plasma EGFR mutation detection in NSCLC patients

Table 3 Comparison of the EGFR mutation status between tumor tissue and plasma in NSCLC patients (N=47)

EGFR genotype	TP and TN^a	cfDNA		Short-length exoTNA
EGFR genotype	TP and TN^a	Mutant type	Wild-type	Mutant type	Wild-type
Mutant type	17	11	6	13	4
Wild-type	124	3	121	0	124
Sensitivity,% (95% CI)		64.7% (38.3–85.8%)		76.5% (50.1–93.2%)
Specificity, % (95% CI)		97.6% (93.1–99.5%)		100.0% (97.1–100.0%)
Accuracy, % (95% CI)		93.6% (88.2–97.0%)		97.2% (92.9–99.2%)

NSCLC non-small cell lung cancer, TP true positive, TN true negative, CI confidence interval
^aTissue EGFR genotyping results were considered ‘true positive’ or ‘true negative.’ Three cases for which tissue EGFR was negative showed positive results using the cobas^® EGFR Mutation Test v2. These results were regarded as ‘true positive.’

ISSN: 1475-2867