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Fig. 1 | Cancer Cell International

Fig. 1

From: (−)-Epigallocatechin-3-gallate derivatives combined with cisplatin exhibit synergistic inhibitory effects on non-small-cell lung cancer cells

Fig. 1

Synthesis of the EGCG derivatives 1–5. Reagents and conditions: a Ac2O, NaOAc, 100 °C, 20 min, 100%; b HBr, AcOH, CH2Cl2, 0 °C, 96%; c NaN3, DMF, 90%; d CH3ONa, CH3OH, rt, 78%; e, i K2CO3, acetone, 55 °C, 12 h, (ii) CH3OH–THF, KOH, 13 h, 0 °C, 11–23%; f propargyl bromide, NaH, DMF, 0 °C, 4 h, 11–45%; g copper(II) acetate, sodium ascorbate, t-BuOH–H2O (1:1), THF, rt, 2 h, 56–78%

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