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Fig. 4 | Cancer Cell International

Fig. 4

From: (−)-Epigallocatechin-3-gallate derivatives combined with cisplatin exhibit synergistic inhibitory effects on non-small-cell lung cancer cells

Fig. 4

Effects of compound 3, cDDP, or a combination of the two drugs on the induction of NSCLC cell apoptosis and the expression of relevant proteins in NCI-H441 cells. a Flow cytometry was used to detect cell apoptosis in NCI-H441 cells treated with various concentrations of compound 3 and cDDP in combination or individually. b, c The ratio of apoptotic cells in each group are expressed as percentages. d The expression levels of Bax and Bcl-2 were determined by western blotting after 12 h of drug treatment, using β-tubulin as the loading control. e, f Quantification of relative Bax and Bcl-2 protein levels. Data represent the average of three independent experiments (mean ± SD). Data represent the average of three independent experiments (mean ± SD). ***p < 0.001 vs the control; ###p < 0.001, ##p < 0.01, cDDP + compound 3 vs compound 3

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Cancer Cell International

ISSN: 1475-2867

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