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Table 2 Main results

From: Prognostic value of YKL-40 in solid tumors: a meta-analysis of 41 cohort studies

Author Outcome HR 95% CI NOS score
Breast cancer
 Johansen 1995 OS 2.2 0.83–5.81 7
 Jensen 2003 OS 2.57 1.6–4.1 9
PFS 1.96 1.2–3.1
 Johansen 2003 OS 1.77 1.03–3.06 8
 Yamac 2008 OS 1.004 1.00–1.07 7
 Wang 2012 OS 1.04 1.02–1.06 7
DFS 1.02 1.00–1.03
Gastrointestinal tumors
 Cintin 1999 OS 1.4 1.1–1.8 8
 Chang 2009 OS 0.99 0.76–1.28 7
 Zhu 2012 OS 1.809 1.259–2.601 8
 Zhu 2012 OS 2.188 1.237–3.870 8
 Schultz 2013 OS 0.69 0.36–1.33 7
OS 1.30 1.03–1.64
 Liu 2014 PFS 1.653 1.123–2.416 7
 Tarpgaard 2014 OS 1.17 1.05–1.30 7
PFS 1.00 0.91–1.09
 Jensen 2016 OS 1.53 1.1–2.13 6
OS 2.89 1.84–4.53
 Thongsom 2016 OS 1.642 0.780–3.455 7
 Gramkow 2017 OS 1.19 1.05–1.34 6
 Fuksiewicz 2018 OS 1.5 0.36–6.2 7
DFS 0.93 0.39–2.24
Ovarian cancer
 Dehn 2003 OS 2.27 1.27–4.06 7
 Høgdall 2003 OS 3.95 1.52–10.273 7
 Høgdall 2009 OS 2.13 1.40–3.25 7
 Boisen 2016 OS 1.97 0.90–4.32 7
PFS 2.91 1.07–7.92
Lung cancer
 Johansen 2004 OS 1.96 1.13–3.40 7
 Choi 2010 OS 3.6 1.25–10.39 7
 Thöm 2010 OS 1.48 1.04–2.10 8
 Xu 2014 OS 1.84 1.08–3.15 7
PFS 1.12 1.01–1.23
 Matsuo 2019 PFS 1.119 0.992–1.262 7
Urologic neoplasms
 Brasso 2006 OS 1.3 1.0–1.7 8
 Johansen 2007 OS 1.0 0.7–1.3 7
 Tschirdewahn 2014 OS 1.837 1.039–3.375 8
 Vom Dorp 2016 OS 3.854 2.222–6.686 8
 Väänänen 2017 OS 3.19 1.38–7.36 7
 Darr 2018 OS 0.933 0.621–1.401 6
Melanoma
 Schmidt 2006 OS 3.6 1.7–7.7 9
 Schmidt 2006 OS 1.9 1.2–2.8 9
 Krogh 2016 OS 1.28 1.05–1.57 8
 Erturk 2017 OS 1.568 0.580–3.051 7
Squamous cell carcinoma of the head and neck
 Roslind 2008 OS 2.16 1.39–3.35 9
Multiple tumors
 Johansen 2009 OS 1.8 1.3–2.5 9
Cervical adenocarcinoma
 Mitsuhashi 2009 DFS 11 1.29–97 8
Glioblastoma     
 Iwamoto 2011 OS 1.2 1.0–1.4 8
 Bernardi 2012 OS 1.97 1.03–3.8 6
 Gállego 2014 OS 1.21 0.89–1.64 7
PFS 1.09 0.83–1.42
  1. HR hazard ratio, CI confidence interval, NOS Newcastle–Ottawa scale, OS overall survival, PFS progression-free survival, DFS disease-free survival